NDLI: Specific inhibition of the enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances.

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Specific inhibition of the enzymic decarboxylation of S-adenosylmethionine by methylglyoxal bis(guanylhydrazone) and related substances.

Content Provider	Semantic Scholar
Author	Corti, Arnaldo Dave, C. Williams-Ashman, H. Guy Mihich, Enrico Schenone, Angelo
Copyright Year	1974
Abstract	Methylglyoxal bis(guanylhydrazone) {1,1'-[(methylethanediylidene)-dinitrilo]diguanidine} is a very potent inhibitor of putrescine-activated S-adenosylmethionine decarboxylases from many different mammalian tissues, including sublines of mouse L1210 leukaemia that are resistant to the drug as well as sublines that are sensitive. The inhibition of purified rat ventral prostate S-adenosylmethionine decarboxylase is competitive with respect to the S-adenosylmethionine substrate, and is much greater in the presence than in the absence of the activator putrescine. Inhibition by the drug depends, among other things, on the nature of the aliphatic amines that can serve as stimulators of rat prostate S-adenosylmethionine decarboxylase. Effects of some congeners of methylglyoxal bis(guanylhydrazone) on the enzyme are described.
File Format	PDF HTM / HTML
DOI	10.1042/bj1390351
Alternate Webpage(s)	http://www.biochemj.org/content/ppbiochemj/139/2/351.full.pdf
PubMed reference number	4447616
Alternate Webpage(s)	https://doi.org/10.1042/bj1390351
Journal	Medline
Volume Number	139
Issue Number	2
Journal	The Biochemical journal
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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