NDLI: Effects of total flavonoids extracted from Polygonum perfoliatum L . on hypolipidemic and antioxidant in hyperlipidemia rats induced by high-fat diet

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Effects of total flavonoids extracted from Polygonum perfoliatum L . on hypolipidemic and antioxidant in hyperlipidemia rats induced by high-fat diet

Content Provider	Semantic Scholar
Author	Wang, Jiaxing Wang, Yu Xu, Cheng Wang, Beilei Yu, Jinggang Kang, Xiaoni Zhou, Lili Qin, Yiliang Liao, Ling Min Zhang, Yuxiang
Copyright Year	2018
Abstract	The tubers of Polygonum perfoliatum L. was usually used as a folk herbal medicine due to its special biological activity. This research aimed to evaluate the bioactive composition and antioxidant and hypolipidemic effects of total flavonoids extracted from Polygonum perfoliatum L. (TFP) on high fat diet induced hyperlipidemic rats. HPLC analysis results showed the main flavonoids composition of TFP were quercetin and rutin. Investigation was performed by administering different oral doses (60, 120 and 240 mg/kg BW/day) of the TFP for four weeks. The levels of serum triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), as well as hepatic antioxidant enzyme activities and melondialdehyde (MDA) level were determined. Experiments showed that the levels of serum lipid, antioxidant enzyme activities and MDA in liver tissue of hyperlipidemia rats had obviously restored by the treatment with the different doses of TFP. These results suggest that TFP from Polygonum perfoliatum L. had demonstrated antioxidant and hypolipidemic effects in vivo, which could become a potential herbal medicine to prevent hyperlipidemia diseases.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.ijcem.com/files/ijcem0069825.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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