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Evidence for antigen-driven T-cell response in unstable angina.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Caligiuri, Giuseppina Paulsson, Gunnar Nicoletti, A. Maseri, Attilio Hansson, Göran K. |
| Copyright Year | 2000 |
| Abstract | BACKGROUND Activation of T cells and macrophages has been associated with unstable angina (UA), but whether this reflects specific immune responses remains unclear. METHODS AND RESULTS We analyzed the repertoire and the length of complementarity-determining region 3 of the T-cell receptor (TCR) beta-chain variable (BV) gene segments of activated lymphocytes in 23 patients with UA, 13 patients with chronic stable angina (CSA), and 6 normal control subjects. We also tested the proliferation of systemic T cells in response to autologous coronary plaque proteins, oxidized LDL, and Chlamydia pneumoniae as candidate antigens, in vitro. The activated T cell-TCRBV repertoire was perturbed in 13 (57%) of 23 UA patients versus 3 (23%) of 13 CSA patients (P=0.016) and was restricted to 6 (28%) of 21 expanded TCRBV families; all were significantly higher in UA than in CSA patients. At least one monotypic or oligotypic activated TCRBV population was found in 15 (65%) of 23 UA patients and in 3 (23%) of 13 CSA patients (P<0.001). Finally, T cells from UA patients, but not from CSA patients or normal control subjects, proliferated in response to autologous proteins from coronary culprit lesions and/or to oxidized LDL. CONCLUSIONS Our findings suggest that the T-cell response observed in UA patients is antigen-driven and directed to antigens contained in the culprit coronary atherosclerotic plaques. |
| Starting Page | 59 |
| Ending Page | 63 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/102/10/1114.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/102/10/1114.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/102/10/1114.full.pdf?download=true |
| PubMed reference number | 10973839v1 |
| Volume Number | 102 |
| Issue Number | 10 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenergic beta-Agonists Angina Pectoris Angina, Unstable Antigens Atherosclerosis Chlamydia Chronic Lymphocytic Leukemia Complementarity Determining Regions Contain (action) Dental Plaque Leukemia, B-Cell Patients Plaque, Atherosclerotic Pneumonia Senile Plaques Stable angina T-Lymphocyte Unstable Medical Device Problem Urinalysis |
| Content Type | Text |
| Resource Type | Article |
