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Organ-specific immunity in canine visceral leishmaniasis: analysis of symptomatic and asymptomatic dogs naturally infected with Leishmania chagasi.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sánchez, Martín Gerardo Aguilar Díaz, Nilka L. Zerpa, Olga Negrón, Emilia Convit, Jacinto Tapia, Félix Jacobo |
| Copyright Year | 2004 |
| Abstract | We characterized key leukocyte immunophenotypes in the liver and spleen of naturally infected dogs from an area in Venezuela endemic for leishmaniasis. Dogs were classified as symptomatic or asymptomatic after serologic and physical analysis. Symptomatic dogs showed a higher parasite burden in the liver and spleen than asymptomatic dogs. The livers of asymptomatic dogs showed an effective immunity with well-organized granulomas walling off parasites in an environment of central memory CD44(lo), CD45RO(hi), activated effector CD44(hi), and CD45RO(hi) T cells. These granulomas also had many major histocompatibility class II+ cells and CD11c+ dendritic cells, and cells expressing CD18 and CD44. In contrast, symptomatic livers showed a non-organized and non-effective infiltrate composed of T cells and heavily parasitized Kupffer cells and a diminished expression of activation molecules. In the spleen, the immune responses of symptomatic and asymptomatic dogs were very similar. The results showed a distinct immune response against Leishmania chagasi in target organs. |
| File Format | PDF HTM / HTML |
| DOI | 10.4269/ajtmh.2004.70.618 |
| PubMed reference number | 15211002 |
| Journal | Medline |
| Volume Number | 70 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://saber.ucv.ve/jspui/bitstream/123456789/4973/1/S%C3%A1nchez%20et%20al%202004%20AMJTMH.pdf |
| Alternate Webpage(s) | http://www.ajtmh.org/docserver/fulltext/14761645/70/6/0700618.pdf?accname=guest&checksum=D55CF898D5839D06207B3C147E9E4CC0&expires=1543081813&id=id |
| Journal | The American journal of tropical medicine and hygiene |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
