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NGF treatment potentiates c-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid
| Content Provider | Semantic Scholar |
|---|---|
| Author | Giovannelli, Lisa Veltri, Maria Casamenti, Fiorella Pepeu, Giancarlo |
| Copyright Year | 2000 |
| Abstract | The induction of the c-fos gene in the rat brain by NGF was studied in a model of acute cholinergic hypofunction, i.e., the lesion of the nucleus basalis magnocellularis (NBM) with quisqualic acid. Choline acetyltransferase and Fos immunoreactivity (IR) in the NBM were analyzed at different times after the excitotoxic lesion. NGF treatment induced a potentiation of Fos expression 4 and 24 h after lesion. The possibility is discussed that c-fos induction is one of the early mechanisms of the neuroprotective action of NGF. |
| Starting Page | 136 |
| Ending Page | 141 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0006-8993(99)02312-4 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0006899399023124 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0006899399023124?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 10627317 |
| Alternate Webpage(s) | https://doi.org/10.1016/S0006-8993%2899%2902312-4 |
| Journal | Medline |
| Volume Number | 853 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |