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Synthesis of vitamin B6 by a mutant of Escherichia coli K12 and the action of 4'-deoxypyridoxine.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Scott, Thomas A. Hockney, R. C. |
| Copyright Year | 1979 |
| Abstract | Mutants of Escherichia coli K12 blocked in the oxidation of pyridoxine 5'-phosphate ('Oxidase' mutants) excreted pyridoxine at an initial rate of 19 pmol h-1 (10(8) bacteria)-1, i.e.0.6 nmol h-1 (mg dry wt)-1, when starved for pyridoxal. Glycolaldehyde, L-phosphoserine, DL-serine and, to a lesser extent, L-leucine stimulated the rate of pyridoxine excretion, but there was no significant stimulation by 2'-hydroxypyridoxine. 4'-Deoxypyridoxine inhibited or stimulated growth of the "Oxidase' mutant, depending on the relative concentrations of added pyridoxal and 4'-deoxypyridoxine. It was concluded that stimulation of growth by 4'-deoxypyridoxine was due to its conversion to pyridoxal. |
| Starting Page | 1 |
| Ending Page | 5 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/micro/110/2/mic-110-2-285.pdf?accname=guest&checksum=8E250D8F8D1C1707228AE42A1F9A5418&expires=1543559687&id=id |
| PubMed reference number | 374679v1 |
| Volume Number | 110 |
| Issue Number | 2 |
| Journal | Journal of general microbiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 4-deoxypyridoxine Alveolar periostitis C57BL/6 Mouse L-Serine Dehydratase Leucine Nanomole Phosphoserine aminotransferase Pyridoxal Vitamin B6 glycolaldehyde mutant oxidation picomole (pM) pyridoxine |
| Content Type | Text |
| Resource Type | Article |
