NDLI: The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors

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The therapeutic potential of targeting the PI3K pathway in pediatric brain tumors

Content Provider	Semantic Scholar
Author	Rogers, Hazel Anne Estranero, Jasper Gudka, Keshni Grundy, Richard Guy
Copyright Year	2017
Abstract	Central nervous system tumors are the most common cancer type in children and the leading cause of cancer related deaths. There is therefore a need to develop novel treatments. Large scale profiling studies have begun to identify alterations that could be targeted therapeutically, including the phosphoinositide 3-kinase (PI3K) signaling pathway, which is one of the most commonly activated pathways in cancer with many inhibitors under clinical development. PI3K signaling has been shown to be aberrantly activated in many pediatric CNS neoplasms. Pre-clinical analysis supports a role for PI3K signaling in the control of tumor growth, survival and migration as well as enhancing the cytotoxic effects of current treatments. Based on this evidence agents targeting PI3K signaling have begun to be tested in clinical trials of pediatric cancer patients. Overall, targeting the PI3K pathway presents as a promising strategy for the treatment of pediatric CNS tumors. In this review we examine the genetic alterations found in the PI3K pathway in pediatric CNS tumors and the pathological role it plays, as well as summarizing the current pre-clinical and clinical data supporting the use of PI3K pathway inhibitors for the treatment of these tumors.
Starting Page	2083
Ending Page	2095
Page Count	13
File Format	PDF HTM / HTML
PubMed reference number	27926496
Journal	Medline
Volume Number	8
Alternate Webpage(s)	http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=13781&path%5B%5D=43822
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.13781
Journal	Oncotarget
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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