Capsaicin increases gastric emptying rate in healthy human subjects measured by 13C-labeled octanoic acid breath test

Content Provider	Semantic Scholar
Author	Debreceni, András Abdel-Salam, Omar M. E. Figler, Mária Juricskay, István Mózsik, Gyula
Copyright Year	1999
Abstract	The role of capsaicin-sensitive primary afferent sensory nerves in the regulation of gastrointestinal motility in human is not clarified yet. In this study, we investigated the effect of 400 microg capsaicin given intragastrically on gastric emptying measured by 13C-octanoic acid breath test in ten healthy human subjects. Four parameters of gastric emptying curves were taken into consideration: 1) maximum value of the curve, 2) time belonging to this maximum, 3) slope of the rising part of the curve and 4) time belonging to the 50% of the area under the curve. Administration of 400 microg capsaicin significantly increased the slope of gastric emptying curve (from 0.1 +/- 0.01 to 0.139 +/- 0.014 U x min(-1), P < 0.05) and significantly decreased the time belonging to the maximum value of emptying curve (from 150 +/- 18 to 75 +/- 12 min, P < 0.05) and the time belonging to the 50% of the area under the curve (from 112 +/- 15 to 99 +/- 14 min, P < 0.05). According to our results 400 microg capsaicin enhances gastric emptying rate in healthy human subjects.
Starting Page	455
Ending Page	460
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/S0928-4257(99)00114-X
PubMed reference number	10674924
Journal	Medline
Volume Number	93
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S092842579900114X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S092842579900114X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0928-4257%2899%2900114-X
Journal	Journal of Physiology-Paris
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article