Haloperidol and reduced haloperidol plasma concentrations after a loading dose regimen with haloperidol decanoate

Content Provider	Semantic Scholar
Author	Jann, Michael W. Weui, Fu-Chuan Lin, Hsin-Nan Piao-Chien, Ching
Copyright Year	1996
Abstract	1. Haloperidol and reduced haloperidol plasma levels were measured in schizophrenic patients who received both oral (10 mg, N=16 and 20 mg, N=4) and depot haloperidol treatment 2. Patients were of Asian ethnicity and were safely and effectively converted from oral to depot therapy using a loading dose regimen using a 100 mg weekly injection interval for 4 weeks, biweekly for one month and then monthly. 3. Significant correlations were found for plasma haloperidol and reduced haloperidol levels and reduced haloperidol/haloperidol ratios between oral and depot therapy in these non-smoking patients. 4. A loading dose regimen is needed due to the long elimination half-life of decanoate of 26 days otherwise steady-state condition will not occur until 34 months of therapy. 5. Patients were maintained on monthly depot treatment for 40 weeks after the loading dose regimen and only one patient relapsed during treatment despite dosage increases. 6. The formation of reduced haloperidol remained consistent for oral and depot haloperidol treatment.
Starting Page	73
Ending Page	86
Page Count	14
File Format	PDF HTM / HTML
DOI	10.1016/0278-5846(95)00293-6
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0278584695002936
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0278584695002936?dgcid=api_sd_search-api-endpoint
PubMed reference number	8861178
Alternate Webpage(s)	https://doi.org/10.1016/0278-5846%2895%2900293-6
Journal	Medline
Volume Number	20
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article