Silenciamiento de posibles genes antivirales en litopenaeus vannamei y su efecto en la susceptibilidad al virus del síndrome de la mancha blanca (wssv)

Content Provider	Semantic Scholar
Author	Robalino, Javier Moran, Audra Miraba, Mayelín
Copyright Year	2011
Abstract	In this study, the antiviral roles of 54 candidate g nes from Litopenaeus vannamei, was evaluated. An experimental infection system was used, to assess t h usceptibility to WSSV of shrimp where each one of the 54 candidate genes was knocked down by means of RNAi. For 41% of genes (22 genes) high levels of mortalit y were observed as a result of their silencing, independen tly of whether the animals were experimentally infe cted with WSSV, and thus their possible roles in the antivira l response could not be determined. Among the remai ning 59% of genes, a phenotype of interest was observed for onl y one gene, whose silencing resulted in significant pro ection from the lethality of WSSV infection. We propose ba sed on these data that this gene, which seems to en c d a putative protease, may participate in regulating th e life cycle and/or the pathogenicity of WSSV. Futu re studies will be needed to verify the phenotypes observed in this study, and especially to determine the possible ro les f the gene identified here as a putative protease in regulatin g the WSSV-host interaction.
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Language	English
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Resource Type	Article