NDLI: The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval.

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The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval.

Content Provider	Semantic Scholar
Author	Mitchell, Anna S. Gaffan, David
Copyright Year	2008
Abstract	Damage to the magnocellular mediodorsal thalamic nucleus (MDmc) in the human brain is associated with both retrograde and anterograde amnesia. In the present study we made selective neurotoxic MDmc lesions in rhesus monkeys and compared the effects of these lesions on memory acquisition and retrieval. Monkeys learned 300 unique scene discriminations preoperatively and retention was assessed in a one-trial preoperative retrieval test. Bilateral neurotoxic lesions of the MDmc, produced by 10 x 1 microl injections of a mixture of ibotenate and NMDA did not affect performance in the postoperative one-trial retrieval test. In contrast, new postoperative learning of a further 100 novel scene discriminations was substantially impaired. Thus, MDmc is required for new learning of scene discriminations but not for their retention and retrieval. This finding is the first evidence that MDmc plays a specific role in memory acquisition.
Starting Page	S302
Ending Page	S304
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/28/1/258.full.pdf
PubMed reference number	18171943v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.4922-07.2008
DOI	10.1523/jneurosci.4922-07.2008
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	28
Issue Number	1
Language	English
Access Restriction	Open
Subject Keyword	Amnesia Amnesia, Anterograde Cell Nucleus Centromedian Thalamic Nucleus Macaca mulatta Medial Dorsal Nucleus Monkeys N-Methylaspartate Neurotoxicity Syndromes Thalamic Nuclei Thalamic structure ibotenate
Content Type	Text
Resource Type	Article

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