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Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Busquet, Perrine Capurro, Valeria Cavalli, Andrea Piomelli, Daniele Reggiani, Angelo Bertorelli, Rosalia |
| Copyright Year | 2012 |
| Abstract | We investigated a possible drug efficacy enhancement obtained by combining inactive doses of galantamine and memantine in the scopolamine-induced amnesia model in mice. We evaluated the effects of the two drugs, either alone or in combination, using the spontaneous alternation and object recognition tasks. In both tests, combination of low doses of galantamine (0.1 mg/kg, s.c.) and memantine (0.5 mg/kg, i.p.), which were sub-active per se, rescued the memory impairment induced by scopolamine (1 mg/kg, i.p.). The results suggest that combinations of galantamine and memantine might provide a more effective treatment of memory impairments in cognitive disorders than either drug used alone. |
| Starting Page | 58 |
| Ending Page | 64 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://cloudfront.escholarship.org/dist/prd/content/qt09r5n4fd/qt09r5n4fd.pdf?t=naqa0d |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/jphs/120/4/120_12166SC/_pdf/-char/en |
| Alternate Webpage(s) | http://escholarship.org/uc/item/09r5n4fd.pdf |
| PubMed reference number | 23149577v1 |
| Volume Number | 120 |
| Issue Number | 4 |
| Journal | Journal of pharmacological sciences |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amnesia Cognition Disorders Galantamine Memantine Memory Disorders Physical Inactivity Scopolamine Hydrobromide mg/kg |
| Content Type | Text |
| Resource Type | Article |
