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Optoelectronic tweezers system for single cell manipulation and fluorescence imaging of live immune cells.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jeorrett, Abigail Helen Neale, Steven L. Massoubre, David Gu, Erdan Henderson, Robert K. Millington, Owain Mathieson, Keith Dawson, Martin D. |
| Copyright Year | 2014 |
| Abstract | A compact optoelectronic tweezers system for combined cell manipulation and analysis is presented. CMOS-controlled gallium nitride micro-LED arrays are used to provide simultaneous spatio-temporal control of dielectrophoresis traps within an optoelectronic tweezers device and fluorescence imaging of contrasting dye labelled cells. This capability provides direct identification, selection and controlled interaction of single T-lymphocytes and dendritic cells. The trap strength and profile for two emission wavelengths of micro-LED array have been measured and a maximum trapping force of 13.1 and 7.6 pN was achieved for projected micro-LED devices emitting at λmax 520 and 450 nm, respectively. A potential application in biological research is demonstrated through the controlled interaction of live immune cells where there is potential for this method of OET to be implemented as a compact device. |
| File Format | PDF HTM / HTML |
| DOI | 10.1364/OE.22.001372 |
| PubMed reference number | 24515144 |
| Journal | Medline |
| Volume Number | 22 |
| Issue Number | 2 |
| Alternate Webpage(s) | https://strathprints.strath.ac.uk/47311/1/oe_22_2_1372.pdf |
| Alternate Webpage(s) | http://eprints.gla.ac.uk/89497/1/89497.pdf |
| Alternate Webpage(s) | https://research-repository.griffith.edu.au/bitstream/handle/10072/67423/100872_1.pdf;sequence=1 |
| Alternate Webpage(s) | https://pureportal.strath.ac.uk/files-asset/33024995/oe_22_2_1372.pdf |
| Alternate Webpage(s) | https://research-repository.griffith.edu.au/bitstream/handle/10072/67423/100872_1.pdf;jsessionid=2659318E5FAE1AB8D349E9EBA6EA21D2?sequence=1 |
| Alternate Webpage(s) | http://www98.griffith.edu.au/dspace/bitstream/handle/10072/67423/100872_1.pdf?sequence=1 |
| Alternate Webpage(s) | https://research-repository.griffith.edu.au/bitstream/handle/10072/67423/100872_1.pdf?sequence=1 |
| Alternate Webpage(s) | http://strathprints.strath.ac.uk/47311/1/oe_22_2_1372.pdf |
| Alternate Webpage(s) | https://doi.org/10.1364/OE.22.001372 |
| Journal | Optics express |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
