NDLI: Efficacy of Terminalia arjuna (Roxb.) on N-nitrosodiethylamine induced hepatocellular carcinoma in rats.

Content Provider	Semantic Scholar
Author	Sivalokanathan, Sarveswaran Ilayaraja, M. Balasubramanian, Maruthaiveeran Periyaswamy
Copyright Year	2005
Abstract	The effect of ethanolic extract of Terminalia arjuna bark on carbohydrate metabolizing enzymes of N-nitrosodiethylamine induced hepatocellular carcinoma in Wistar albino rats were studied. The plasma and liver glycolytic enzymes such as hexokinase, phosphoglucoisomerase, aldolase were significantly increased in cancer induced animals while glyconeogenic enzyme, glucose-6-phosphatase was decreased. These enzymes were reverted significantly to near normal range in treated animals after oral administration of T. arjuna for 28 days. The modulation of the enzymes constitute the depletion of energy metabolism leads to inhibition of cancer growth. This inhibitory activity may be due to the anticancer activity of constituents present in the ethanolic extract of T. arjuna.
File Format	PDF HTM / HTML
PubMed reference number	15816414
Journal	Medline
Volume Number	43
Issue Number	3
Alternate Webpage(s)	http://nopr.niscair.res.in/bitstream/123456789/23086/1/IJEB%2043(3)%20264-267.pdf
Journal	Indian journal of experimental biology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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