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Vaccination with a Haemophilus influenzae type b conjugate vaccine reduces oropharyngeal carriage of H. influenzae type b among Gambian children.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Adegbola, Richard A. Mulholland, Edward Kim Secka, Ousman Jaffar, Shabbar Greenwood, Brian |
| Copyright Year | 1998 |
| Abstract | The effect of a Haemophilus influenzae type b (Hib) polyribosylribitol phosphate-tetanus toxoid conjugate vaccine (Hib/PRP-T) on oropharyngeal carriage of Hib was studied during an efficacy trial in Gambian infants. Children were vaccinated with Hib/PRP-T and diphtheria-tetanus toxoids-pertussis (DTP) or DTP alone at ages 2, 3, and 4 months. Groups of 1000 children aged 1-2 years were studied each year for 4 years. Hib was detected by production of a halo on antiserum agar plates. Carriage was significantly lower among children fully vaccinated with Hib/PRP-T given with DTP (4.4%; 95% confidence interval [CI], 3.8%-5.7%) than among children fully vaccinated with DTP alone (11.0%; 95% CI, 8.9%-13.0%) (protective effect adjusted by year = 60%; 95% CI, 44%-72%; P < .001). Hib carriage varied by year among nonvaccinated children. Hib conjugate vaccines are likely to produce a herd protective effect in underdeveloped communities, as recorded in Europe and the United States. |
| Starting Page | 1 |
| Ending Page | 8 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jid/177/6/10.1086/517440/2/177-6-1758.pdf?Expires=1492600119&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=NZy-0meG7xgeW0dH7riGQEN6FZMafjC6LVPIstHkQJJeAJ3Nk526i-Po0awPRmaCup4uwOErsPbD-muZl85SzK9tAMI0cRskvvNSxInyqUnu9kApFRThSdl8kmV74t0InoN1tViBXlBQB6pTzaT-FCNGA7ua-MtOi2b689dwL2DGnkVDxs3xpNjMs5PyzeTSVrEGy4IxiJk8e~q3LoqSWaOseTIiw3kZBtXTpi6HtJubwO-n~7EFq-b1~lX89cUvIGXS8NlZS9xPQ1cbkCKxC7pqi1-DUHblvDiRMz0bCGNtZ9XZInXuspHf8ETszpn9yHyZe1tYgMLo4k0OJIwhXA__ |
| PubMed reference number | 9607866v1 |
| Volume Number | 177 |
| Issue Number | 6 |
| Journal | The Journal of infectious diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Agar Chancroids Community Confidence Intervals Diphtheria Diphtheria-Tetanus-(whole-cell) Pertussis Vaccine Haemophilus influenzae Ab:MCnc:Pt:Ser:Qn Haemophilus influenzae type b Hemophilus Immune Sera Immunostimulating conjugate (antigen) Influenza One Thousand Oropharyngeal disorders Phase I/II Trial Toxoids Vaccines, Conjugate inorganic phosphate tetanus toxoid vaccine, inactivated |
| Content Type | Text |
| Resource Type | Article |
