NDLI: Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from monascus purpureus NTU 568.

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Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from monascus purpureus NTU 568.

Content Provider	Semantic Scholar
Author	Hsu, Li-Chuan Liang, Yu-Han Kuo, Yao-Haur Pan, Tzu-Ming
Copyright Year	2011
Abstract	An azaphilonidal derivative monaphilone A (MA) was recently isolated from the fermented products of Monascus purpureus NTU 568 by our laboratory. We report here the exploration of apoptosis-related and anti-inflammatory properties of MA and ankaflavin (AK) by some experiments about inducing death of human laryngeal carcinoma cell line HEp-2 and reducing inflammatory responses on murine macrophage RAW 264.7 cells. We employed a ssDNA enzyme-linked immunosorbent assay (ELISA) kit to investigate the nuclear changes of early apoptosis induced by AK and MA on HEp-2 cells and used a western blot and an enzyme activity assay to demonstrate the activation of caspase-3, caspase-8, and caspase-9 by MA and AK. Our studies revealed that AK and MA may decrease lipopolysaccharide (LPS)-induced inflammatory responses, including nitrite productions and expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) in RAW 264.7 cells. All evidence support that azaphilonidal derivatives from M. purpureus NTU 568, such as AK and MA, are suitable for the development of chemotherapy or chemopreventive agents.
File Format	PDF HTM / HTML
DOI	10.1021/jf103652n
PubMed reference number	21261255
Journal	Medline
Volume Number	59
Issue Number	4
Alternate Webpage(s)	http://ir.cmu.edu.tw/ir/bitstream/310903500/40216/1/20110502160450.pdf
Alternate Webpage(s)	https://doi.org/10.1021/jf103652n
Journal	Journal of agricultural and food chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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