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Diagnostic management of pulmonary embolism using clinical assessment, plasma D-dimer assay, complete lower limb venous ultrasound and helical computed tomography of pulmonary arteries. A multicentre clinical outcome study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Elias, Antoine Cazanave, Alain Elias, Marie Chabbert, Valérie Juchet, Henri Paradis, Hélène Carrière, Philippe Nguyen, Françoise Didier, Alain Galinier, Michel Colin, Cyrille Lauque, Dominique Joffre, F. Rousseau, Hervé |
| Copyright Year | 2005 |
| Abstract | The objective of the study was to assess the clinical validity of a non-invasive diagnostic strategy for acute pulmonary embolism using clinical assessment combined with both ELISA D-dimer and complete lower limb ultrasound (US) examination of proximal and distal veins, before single-detector helical computed tomography (CT) of pulmonary arteries. We expected the strategy to have a high diagnostic exclusion power and to safely decrease the number of CT scans. This prospective, multicenter outcome study included 274 consecutive outpatients. All underwent a priori clinical probability, D-dimer and bilateral complete lower limb US assessments. Only patients with a high clinical probability and both tests negative, or positive D-dimer and negative US assessments, underwent CT. This was deemed necessary in 114 patients (42%). At baseline, venous thromboembolism (VTE) was detected in 110 patients (40%), either by US showing proximal (n=65) or distal (n=36) thrombosis, or by CT (n=9). Anticoagulant was withheld in the remaining patients with negative results in both D-dimer and US but a non-high clinical probability (n=59), or in both US and CT (n=90), or with negative US (n=6) and inadequate CT (n=9). All patients underwent a three-month clinical follow-up. VTE occurred in one patient with inadequate CT, yielding an incidence of 0.6% [95% confidence interval: 0.1-3.4]. No patient died from VTE or had major bleeding. Using clinical probability, ELISA D-dimer and complete US before helical CT is a safe strategy resulting in a substantial reduction in CT scans. |
| Starting Page | 398 |
| Ending Page | 406 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://th.schattauer.de/en/contents/archive/issue/763/manuscript/4120/download.html |
| PubMed reference number | 15886818v1 |
| Volume Number | 93 |
| Issue Number | 5 |
| Journal | Thrombosis and haemostasis |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anticoagulants Arterial system Cessation of life Confidence Intervals Cooley's anemia Detectors Evaluation procedure Exclusion Hemorrhage Lower Extremity Outpatients Patients Pulmonary Embolism Pulmonary artery structure Single Photon Emission Computed Tomography Computed Tomography Thrombosis Tomography, Spiral Computed Veins Venous Thromboembolism X-Ray Computed Tomography |
| Content Type | Text |
| Resource Type | Article |
