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Alkaloid Sequestration by Papaver somniferum Latex
| Content Provider | Semantic Scholar |
|---|---|
| Author | Homeyer, B. C. Roberts, Margaret F. |
| Copyright Year | 1984 |
| Abstract | Abstract The 1000 x g organelles of Papaver somniferum latex have been shown to accumulate rapidly, large quantities of alkaloids (0.05- 1 mg/mg organelle protein), particularly morphine, thebaine, codeine and papaverine and have been found to exhibit a surprising degree of specificity for the accumulation of these alkaloids. The uptake of alkaloid is independent of temperature and does not show a requirement for ATP 10-3 ᴍ, Mg2+ 10-3 ᴍ, or KCl 10-3 ᴍ. It is unaffected by known ATPase inhibitors (chlormadinone acetate 2.5 × 10-5 ᴍ, N,N-dicyclohexylcarbo- diimide 5 × 10-4 ᴍ and sodium vanadate 10-4 ᴍ) but showed considerable increase in morphine accumulation in the presence of 4-chloromercumbenzoate 5 x 10-4 ᴍ, while N-methylmaleimide 5 × 10-4 ᴍ had no effect, and carbonylcyanide 4-(trifluoromethoxy)phenylhydrazone 5 × 10-4 ᴍ caused a reduction (ca. 30%) of morphine uptake. An acid medium, pH 4.5-5.5, also results in decreased morphine uptake. |
| Starting Page | 876 |
| Ending Page | 881 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1515/znc-1984-9-1004 |
| Volume Number | 39 |
| Alternate Webpage(s) | http://zfn.mpdl.mpg.de/data/Reihe_C/39/ZNC-1984-39c-0876.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
