NDLI: Polymorphism of Neisseria meningitidis penA gene associated with reduced susceptibility to penicillin.

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Polymorphism of Neisseria meningitidis penA gene associated with reduced susceptibility to penicillin.

Content Provider	Semantic Scholar
Author	Antignac, A. Bonnaud Kriz, Paula Tzanakaki, Georgina Alonso, José Mario Taha, Muhamed Kheir
Copyright Year	2001
Abstract	We studied polymorphism of penA (which encodes penicillin-binding protein 2) in 13 strains of Neisseria meningitidis susceptible to penicillin (pen(S)) and 12 strains with reduced susceptibility to penicillin (pen(I)). These strains differed in geographical origin. Serological and genetic typing showed that they were highly diverse and belonged to several genetic lineages. Restriction analysis and DNA sequencing of penA showed that all pen(S) strains had the same penA allele regardless of genetic group, whereas pen(I) strains harboured various penA alleles. Transformation with amplicons of penA and genomic DNA from several pen(I) strains conferred the pen(I) phenotype on a pen(S) strain. Thus, reduction in susceptibility to penicillin is directly related to changes in penA and analysis of penA polymorphisms could be used as a reliable tool for characterizing meningococcal strains in terms of their susceptibility to penicillin.
Starting Page	67
Ending Page	67
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/jac/47/3/10.1093_jac_47.3.285/1/470285.pdf?Expires=1492932321&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=Bhi4u9yePU~ee4aPLebN1lWnJnlnFzegpYEQ~HT--Zvo3rOAqrXXaQmhyUlSFAx24UccXA706Opzx1HtUmWKZ~ib6gOI0VSfsNSQCryXK4SsKqlXQqmbY-oK19vSkH8BP5FzX9KucITf~1WW~tOZll6dL~lzQzGMrG-0cUYc~KlOriV~UuEummSSkv2weMbxvCVs0Tz7wq04PLJDJvwwAK9XLSEk06WWTEKn0yAaXC28IMBljcpsc1WqNa7q375EfJYpHNUKfFGSd5siya~pu6oLl69O8EQNmEr5vG8ZAdgXnWuxGIOVtCg5GYTK6oq1JdnTdzQl8JEQ7nnRA6gcBQ__
PubMed reference number	11222561v1
Volume Number	47
Issue Number	3
Journal	The Journal of antimicrobial chemotherapy
Language	English
Access Restriction	Open
Subject Keyword	Genetic Polymorphism Neisseria meningitidis Penicillin-Binding Proteins Penicillins
Content Type	Text
Resource Type	Article

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