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Sudden unexpected death in infancy (SUDI).
| Content Provider | Semantic Scholar |
|---|---|
| Author | Loughrey, Clodagh M. Preece, Michael A. Green, A. |
| Copyright Year | 2005 |
| Abstract | Rigorous metabolic investigation is essential Sudden infant death syndrome (SIDS) risk reduction campaigns have resulted in a significant decline in the incidence of SIDS.1 However, SIDS remains the major single cause of death in children in developed countries, with a reported incidence, together with unascertained deaths, of approximately 1/3000 live births.1,2 SIDS is in essence a diagnosis of exclusion, although there are inconsistencies in how it is applied, and some pathologists feel that it is not adequately defined.3,4 In a study of the various causes of sudden unexpected death in infancy (SUDI), the most common non-SIDS diagnosis was infection (7.1% of 623 cases), followed by cardiovascular anomaly (2.7%), child abuse (2.6%), and metabolic/genetic disorders (2.1%).5 Cardiovascular defects and serious infection are potentially easier to diagnose at necropsy than many of the inherited metabolic disorders that may contribute to SUDI. Importantly, it was noted that a non-SIDS diagnosis was reached much more frequently in centres with expertise in paediatric pathology (18% v 6%).5 Therefore, inherited metabolic disorders (IMDs) or other genetic disorders may be underdiagnosed as a cause of SUDI in less specialist centres. IMD as a cause of SUDI will probably constitute a greater proportion of all cases of SUDI as the incidence of total SUDI falls, partly because of a decline in the incidence of other causes of SUDI, and possibly more consistent application of the diagnostic criteria for SUDI; however, an important factor will be improved detection of the various metabolic causes of SUDI. “Inherited metabolic disorders or other genetic disorders may be underdiagnosed as a cause of sudden unexplained death in infancy in less specialist centres” Where SUDI occurs in more than one … |
| File Format | PDF HTM / HTML |
| DOI | 10.1136/jcp.2004.020677 |
| PubMed reference number | 15623476 |
| Journal | Medline |
| Volume Number | 58 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://jcp.bmj.com/content/jclinpath/58/1/20.full.pdf |
| Alternate Webpage(s) | https://www.sudiscotland.org.uk/wp-content/uploads/2015/06/Staff_Support_Leaflet.pdf |
| Journal | Journal of clinical pathology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
