Loading...
Please wait, while we are loading the content...
Similar Documents
Non Secretory Multiple Myeloma Presenting as Pathological Fracture Bilateral Humerii : A case report
| Content Provider | Semantic Scholar |
|---|---|
| Author | Faizan, Mohd Shaan, Ziaul Hoda Jilani, Latif Zafar Abbas, Mazhar |
| Copyright Year | 2017 |
| Abstract | Plasma cell neoplasms comprise of spectrum of diseases characterized by clonal proliferation and accumulation of terminally differentiated B cells. This spectrum comprise of conditions as benign as Monoclonal Gammopathy of Undetermined Signif icance (MGUS); indolent conditions like Waldenström’s macroglobulinemia on the one end and more malignant disorders like multiple myeloma and plasma cell leukemia on the other. These disorders have a common feature on serum protein electrophoresis that is the production of single monoclonal peak (M component). Among patients with multiple myeloma, 70% have their M component comprising IgG and 20% having IgA. Production of monoclonal light chains only represents 5 10%. Less than 1% of patients produce monoclonal IgD, IgE, IgM or have non-secretory myeloma [1]. Non Secretory Multiple Myeloma (NSMM) comprise of 1-5% of all multiple myeloma cases [2]. It presents with diagnostic difficulty as there is absence of detectable monoclonal proteins in the serum as well as urine [1]. The plasma cells are unable to secrete the monoclonal immunoglobulin into the blood. Immunoglobulin is typically present in the cytoplasm of neoplastic plasma cells as confirmed by immunofluorescence study. We report this case due to it being very rare and presenting a diagnostic challenge to the treating surgeon. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jbjdonline.com/wp-content/uploads/2017/04/14.-JBJD-Jan-June-2017-Non-Secretory-Multiple-Myeloma-Presenting-as-Pathological-Fracture-Bilateral-Humeri.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
