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Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Welin, Eric R. Warkentin, Alexander Conrad, Jay C. Millan, David W. C. Mac |
| Copyright Year | 2015 |
| Abstract | The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective α-cyanoalkylation of aldehydes. This synergistic catalysis protocol allows for the coupling of two highly versatile yet orthogonal functionalities, allowing rapid diversification of the oxonitrile products to a wide array of medicinally relevant derivatives and heterocycles. This methodology has also been applied to the total synthesis of the lignan natural product (-)-bursehernin. |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/anie.201503789 |
| PubMed reference number | 26130043 |
| Journal | Medline |
| Volume Number | 54 |
| Issue Number | 33 |
| Alternate Webpage(s) | http://www.princeton.edu/chemistry/macmillan/publications/cyanoalkylation.pdf |
| Alternate Webpage(s) | https://www.princeton.edu/chemistry/macmillan/publications/cyanoalkylation.pdf |
| Alternate Webpage(s) | https://doi.org/10.1002/anie.201503789 |
| Journal | Angewandte Chemie |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |