Loading...
Please wait, while we are loading the content...
Similar Documents
Modelos matemáticos aplicados na avaliação da mecânica respiratória em camundongos com desafios de agonista da musculatura lisa.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Aoki, Fabio Gava |
| Copyright Year | 2013 |
| Abstract | Mathematical models are used as tools in the assessment of respiratory mechanics for the understanding of the physiology and pathologies of the respiratory system. This study aimed to assess the respiratory mechanics by applying mathematical models in mice subjected to challenges with methacholine. Emphasis was placed on linear single-compartment model and its nonlinear variants. C57BL/6 mice (n = 8) were tracheostomized, mechanically ventilated (flexiVent, SCIREQ, Canada) and disturbances in volume were applied to the modeling of the respiratory system. The experimental protocol was developed in order to analyze the variation of respiratory parameters during the application of the bronchoactive agent. The division of quasisinusoidal signal in expirations and inspirations during the forced oscillation technique (FOT) with frequency perturbation of 2.5 Hz was also observed. Based on that, a proper computational routine was developed in order to analyze the experiments in the mechanical ventilator and the advantages and disadvantages of the applied mathematical models. The results demonstrated an increase in the standard deviation of the linear single-compartment model and its nonlinear variants parameters after the application of bronchoconstrictor. It is believed that this large variation in the parameters relates to the parenchyma stiffening and to the heterogeneity of pulmonary ventilation after the use of the drug. Due to the fact that the correlation between the model parameters and the physiology occurred only in the linear model, it is believed that this is still the most suitable model in the assessment of respiratory mechanics. Nonlinear variations of the single-compartment model would be indicated only as an option, for example, in cases where the linear model is incapable of performing appropriate fits or when additional information about the respiratory system is required. |
| File Format | PDF HTM / HTML |
| DOI | 10.11606/D.3.2013.tde-01082013-153108 |
| Alternate Webpage(s) | https://www.teses.usp.br/teses/disponiveis/3/3142/tde-01082013-153108/publico/Dissertacao_FabioAoki_unprotected.pdf |
| Alternate Webpage(s) | https://doi.org/10.11606/D.3.2013.tde-01082013-153108 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
