NDLI: Fe-Catalyzed Cross-Coupling of Alkyl Halides with Alkynyl Grignard Reagents

Content Provider	Semantic Scholar
Author	Knochel, Paul Steib, Andreas K.
Copyright Year	2012
Abstract	Significance: The authors report a novel coupling of primary and secondary alkyl halides with alkynylmagnesium reagents with iron catalysis. The use of a bisphosphine ligand bearing peripheral steric bulk as well as slow addition of the Grignard reagent suppress undesired side reactions. Comment: By using starting materials with two potential reactive sites, for example C(sp3)–Br and C(sp2)–OTf, and applying the reported ironcatalyzed cross-coupling with an alkynyl Grignard reagent, the C(sp)–C(sp3)-coupled products are obtained in excellent yields. Alkyl X BrMg R catalyst (3–5 mol%) THF, 60 °C, 2–4 h + Alkyl R
Starting Page	193
Ending Page	193
Page Count	1
File Format	PDF HTM / HTML
DOI	10.1055/s-0031-1290007
Volume Number	8
Alternate Webpage(s)	https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0031-1290007.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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