Metabolism of [3H]equilin in normal and malignant human endometrium and in endometrial adenocarcinoma transplanted into nude mice

Content Provider	Semantic Scholar
Author	Bhavnani, Bhagu R. Gerulath, Alan H.
Copyright Year	1991
Abstract	One of the main components of conjugated equine estrogens is equilin sulfate and this estrogen in postmenopausal women is metabolized to 17 beta-dihydroequilin, 17 beta-dihydroequilenin and equilenin. To investigate the possibility that some of these estrogens may be formed directly in the target tissues, we studied the in vitro metabolism of [3H]equilin in various types of normal and malignant human endometrium, including adenocarcinoma grown in athymic nude mice. The results indicate that normal and neoplastic human endometrium can form the above three metabolites. The highest level of 17 beta-reduced products were isolated from the normal secretory endometrium. Equilenin was the most abundant metabolite isolated from both the normal and malignant endometrium. The formation of [3H]equilenin indicates the presence of a 6,8(9) steroid dehydrogenase-isomerase in the human endometrium. The formation of 17 beta-dihydroequilin in the endometrium may be of importance as this estrogen is 8 times more potent as a uterotrophic agent than equilin and estrone.
Starting Page	433
Ending Page	439
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/0960-0760(91)90331-X
PubMed reference number	2031858
Journal	Medline
Volume Number	38
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/096007609190331X
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/096007609190331X?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0960-0760%2891%2990331-X
Journal	The Journal of Steroid Biochemistry and Molecular Biology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article