Structure of the human VIPR 2 gene for vasoactive intestinal peptide receptor type 2

Content Provider	Semantic Scholar
Author	Lutza, E. M. Shenb, S. Mackayb, M. Westb, K. Harmarb, A. J.
Copyright Year	1999
Abstract	The VPAC2 (vasoactive intestinal peptide (VIP)2) receptor is a seven-transmembrane spanning G protein-coupled receptor which responds similarly to VIP and pituitary adenylate cyclase activating polypeptide (PACAP) in stimulating cAMP production. Recently, we reported the localisation of the human VPAC2 receptor gene (VIPR2) to chromosome 7q36.3 (Mackay, M. et al. (1996) Genomics 37, 345^353). Here, we describe the characterisation of the VIPR2 gene structure and promoter region. The VIPR2 gene is encoded by 13 exons, the initiator codon of the 438 amino acid open reading frame is located in exon 1 and the termination signal and a poly-adenylation signal sequence are located in exon 13. The 5P untranslated region extends 187 bp upstream of the initiator codon and is extremely GC-rich (80%). The poly-adenylation signal is located 2416 bp downstream of the stop codon. Intron sizes range from 68 bp (intron 11) to 45 kb (intron 4) and the human gene spans 117 kb. z 1999 Federation of European Biochemical Societies.
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Alternate Webpage(s)	https://www.pure.ed.ac.uk/ws/files/14018284/Structure_of_the_human_VIPR2_gene_for_vasoactive_intestinal_peptide_receptor_type_2.pdf
Alternate Webpage(s)	http://www.research.ed.ac.uk/portal/files/14018284/Structure_of_the_human_VIPR2_gene_for_vasoactive_intestinal_peptide_receptor_type_2.pdf
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Language	English
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Content Type	Text
Resource Type	Article