NDLI: Evidence for neurogenesis in the adult mammalian substantia nigra.

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Evidence for neurogenesis in the adult mammalian substantia nigra.

Content Provider	Semantic Scholar
Author	Zhao, Ming Momma, Stefan Delfani, Kioumars Carlén, Marie Cassidy, Robert Johansson, Clas B. Brismar, Hjalmar Shupliakov, Oleg Frisén, Jonas Janson, Ann Marie
Copyright Year	2003
Abstract	New neurons are generated from stem cells in a few regions of the adult mammalian brain. Here we provide evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain and show that the rate of neurogenesis is increased after a lesion. The number of new neurons generated under physiological conditions in substantia nigra pars compacta was found to be several orders of magnitude smaller than in the granular cell layer of the dentate gyrus of the hippocampus. However, if the rate of neuronal turnover is constant, the entire population of dopaminergic neurons in substantia nigra could be replaced during the lifespan of a mouse. These data indicate that neurogenesis in the adult brain is more widespread than previously thought and may have implications for our understanding of the pathogenesis and treatment of neurodegenerative disorders such as Parkinson's disease.
File Format	PDF HTM / HTML
DOI	10.1073/pnas.1131955100
PubMed reference number	12792021
Journal	Medline
Volume Number	100
Issue Number	13
Alternate Webpage(s)	http://www.pnas.org/content/100/13/7925.full.pdf
Alternate Webpage(s)	http://keck.bioimaging.wisc.edu/Neuro670/reqreading/EvidenceForNeurogenesisInTheAdultMammalianSubstantiaNigra.pdf
Alternate Webpage(s)	http://www.neurogenesisresearch.com/Neurogenesis_S_Nigra.pdf
Alternate Webpage(s)	http://www.keck.bioimaging.wisc.edu/neuro670/reqreading/EvidenceForNeurogenesisInTheAdultMammalianSubstantiaNigra.pdf
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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