Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus

Content Provider	Semantic Scholar
Author	Ashe, Paula C. Chlan-Fourney, Jennifer Juorio, Augusto V. Li, Xinmin
Copyright Year	2002
Abstract	Increasing evidence suggests that schizophrenia is a neurodevelopmental disorder with a progressive course characterized by worsening of symptoms and morphological alterations within the brain. This suggests that a neurodegenerative component may exist in schizophrenia. The role of brain-derived neurotrophic factor (BDNF) in neurodevelopment, cell viability and synaptic plasticity led to the investigation of BDNF as a potential candidate molecule in the pathophysiology of schizophrenia. BDNF mRNA was examined by in situ hybridization in the prefrontal cortex and hippocampus of animals with neonatal ibotenic acid lesions of the ventral hippocampus, a putative neurodevelopmental animal model of schizophrenia. Results demonstrate that animals with neonatal ibotenic acid lesions of the ventral hippocampus have reduced basal levels of BDNF mRNA. It is possible that alterations in this trophic factor render animals more susceptible to neurodegenerative insults.
Starting Page	126
Ending Page	135
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1016/S0006-8993(02)03176-1
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006899302031761
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006899302031761?dgcid=api_sd_search-api-endpoint
PubMed reference number	12426055
Alternate Webpage(s)	https://doi.org/10.1016/S0006-8993%2802%2903176-1
Journal	Medline
Volume Number	956
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article