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Symbolic-Numeric Estimation of Kinetic Parameters in Biochemical Pathways by Quantifier Elimination
| Content Provider | Semantic Scholar |
|---|---|
| Author | Orii, Shigeo Anai, Hirokazu Horimoto, Katsuhisa |
| Copyright Year | 2005 |
| Abstract | The sequencing of complete genomes allows analyses of the interactions between various biological molecules on a genomic scale, which prompted us to simulate the global behaviors of biological phenomena on the molecular level. One of the basic mathematical problems in the simulation is the parameter optimization in the kinetic model for complex dynamics, and many optimization methods have been designed. Here, we introduce a new approach to optimize the parameters in biological kinetic models by quantifier elimination (QE), in combination with numerical simulation methods [3]. The optimization method was applied to a model for the inhibition kinetics of HIV proteinase with ten parameters and nine variables [1, 2]. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jsbi.org/pdfs/journal1/GIW05/GIW05P117.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
