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Endoscopic Treatment of Vesicoureteral Reflux
| Content Provider | Semantic Scholar |
|---|---|
| Author | Puri, Prem |
| Copyright Year | 2005 |
| Abstract | Primary vesicoureteral reflux (VUR) is the most common urological anomaly in children and has been reported in 30 to 50% of those who present with urinary tract infection (UTI). The association of VUR, UTI and renal parenchymal damage is well known. Reflux nephropathy is the cause of endstage renal failure in 3–25% of children and 10–15% of adults. There has been no consensus regarding when medical or surgical therapy should be used. A number of prospective studies have shown low probability of spontaneous resolution of high grade of reflux during conservative follow-up. Furthermore, all of these studies revealed that observation therapy does carry an ongoing risk of renal scarring. Open surgery is the standard treatment for VUR when indicated. Although ureteral reimplantation is effective, this operation is not free of complications. Since its introduction endoscopic correction of VUR has become an established alternative to longterm antibiotic prophylaxis and open surgical treatment. Recently, we published our data regarding long-term effectiveness of endoscopic STING (subureteral injection of polytetrafluoroethylene) for VUR in 258 patients, and its success was confirmed in our 17-year follow-up. Our study as well as long-term studies from others have not shown any clinical untoward effects with the use of polytetrafluoroethylene for the treatment of vesicoureteral reflux. Recently, a number of other tissue augmenting substances have been used endoscopically for subureteral injection. Dextranomer microspheres in sodium hyaluronic acid solution (Deflux) is a recently developed organic substance comprising 80 to 250 μm microspheres. It has been reported that dextranomer/hyaluronic acid copolymer is biodegradable, has no immunogenic properties and has no potential for malignant transformation. Dextranomer microspheres in sodium hyaluronic acid solution consist of microspheres of dextranomers mixed in a 1% high molecular weight sodium hyaluronan solution. Each millilitre of the system contains 0.5 ml sodium hyaluronan and 0.5 ml microspheres. Endoscopic Treatment of Vesicoureteral Reflux |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://eknygos.lsmuni.lt/springer/355/493-498.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anomaly detection Antibiotic Prophylaxis Catheterization, Ureteral Cicatrization Copolymer Deflux Ebstein Anomaly Eighty Gastroesophageal reflux disease Hyaluronic Acid Kidney Diseases Microspheres Molecular Weight Patients Polytetrafluoroethylene Prospective search Renal Cell Carcinoma Renal Insufficiency STING Scientific Publication Sodium Sphincterotomy, Endoscopic Spontaneous order Surgical Replantation Thioctic Acid Urinary tract infection Vesico-Ureteral Reflux |
| Content Type | Text |
| Resource Type | Article |
