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Independent modification of baroreceptor and exercise pressor reflex function by nitric oxide in nucleus tractus solitarius.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Smith, Scott A. Mitchell, Jere H. Li, Jianhua |
| Copyright Year | 2005 |
| Abstract | It has been suggested that nitric oxide (NO) is a key modulator of both baroreceptor and exercise pressor reflex afferent signals processed within the nucleus tractus solitarius (NTS). However, studies investigating the independent effects of NO within the NTS on the function of each reflex have produced inconsistent results. To address these concerns, the effects of microdialyzing 10 mM L-arginine, an NO precursor, and 20 mM N(G)-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, into the NTS on baroreceptor and exercise pressor reflex function were examined in 17 anesthetized cats. Arterial baroreflex regulation of heart rate was quantified using vasoactive drugs to induce acute changes in mean arterial pressure (MAP). To activate the exercise pressor reflex, static hindlimb contractions were induced by electrical stimulation of spinal ventral roots. To isolate the exercise pressor reflex, contractions were repeated after barodenervation. The gain coefficient of the arterial cardiac baroreflex was significantly different from control (-0.24 +/- 0.04 beats.min(-1).mmHg(-1)) after the dialysis of L-arginine (-0.18 +/- 0.02 beats.min(-1).mmHg(-1)) and L-NAME (-0.29 +/- 0.02 beats.min(-1).mmHg(-1)). In barodenervated animals, the peak MAP response to activation of the exercise pressor reflex (change in MAP from baseline, 39 +/- 7 mmHg) was significantly attenuated by the dialysis of L-arginine (change in MAP from baseline, 29 +/- 6 mmHg). The results demonstrate that NO within the NTS can independently modulate both the arterial cardiac baroreflex and the exercise pressor reflex. Collectively, these findings provide a neuroanatomical and chemical basis for the regulation of baroreflex and exercise pressor reflex function within the central nervous system. |
| Starting Page | 1250 |
| Ending Page | 1260 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajpheart.physiology.org/content/ajpheart/288/5/H2068.full.pdf |
| PubMed reference number | 15604127v1 |
| Volume Number | 288 |
| Issue Number | 5 |
| Journal | American journal of physiology. Heart and circulatory physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Activation action Arginine Baroreflex BaseLine dental cement Cardiac Chronotropy Cell Nucleus Coefficient Electric stimulation technique Esters Modulator Device Component NG-Nitroarginine Methyl Ester NTS gene Nervous system structure Nitric Oxide Synthase Nucleus solitarius Plant Roots Pressoreceptors Reflex action Ventral Roots torr |
| Content Type | Text |
| Resource Type | Article |
