NDLI: Hepatocellular carcinoma in non-alcoholic steatohepatitis: Current knowledge and implications for management

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Hepatocellular carcinoma in non-alcoholic steatohepatitis: Current knowledge and implications for management

Content Provider	Semantic Scholar
Author	Cholankeril, George Patel, Ronak M. Khurana, Sandeep Satapathy, Sanjaya K.
Copyright Year	2017
Abstract	With the prevalence of hepatitis C virus expected to decline, the proportion of hepatocellular carcinoma (HCC) related to non-alcoholic steatohepatitis (NASH) is anticipated to increase exponentially due to the growing epidemic of obesity and diabetes. The annual incidence rate of developing HCC in patients with NASH-related cirrhosis is not clearly understood with rates ranging from 2.6%-12.8%. While multiple new mechanisms have been implicated in the development of HCC in NASH; further prospective long-term studies are needed to validate these findings. Recent evidence has shown a significant proportion of patients with non-alcoholic fatty liver disease and NASH progress to HCC in the absence of cirrhosis. Liver resection and transplantation represent curative therapeutic options in select NASH-related HCC patients but have placed a significant burden to our healthcare resources and utilization. Currently NASH-related HCC is the fastest growing indication for liver transplant in HCC candidates. Increased efforts to implement effective screening and preventative strategies, particularly in non-cirrhotic NASH patients, are needed to reduce the future impact imposed by NASH-related HCC.
Starting Page	533
Ending Page	543
Page Count	11
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://pdfs.semanticscholar.org/7eba/166c3a17c22a7cfed3ada7b8d99c4a5abd22.pdf
PubMed reference number	28469809v1
Alternate Webpage(s)	https://doi.org/10.4254/wjh.v9.i11.533
DOI	10.4254/wjh.v9.i11.533
Journal	World journal of hepatology
Volume Number	9
Language	English
Access Restriction	Open
Subject Keyword	Alcoholic Liver Diseases Chemical and Drug Induced Liver Injury Diabetes Mellitus Fatty Liver, Alcoholic Fibrosis Hepatectomy Hepatitis C virus Hepatitis C, Chronic Liver carcinoma Non-alcoholic Fatty Liver Disease Obesity Patients Steatohepatitis Transplantation of liver non-T, non-B, cALLa positive childhood acute lymphoblastic leukemia
Content Type	Text
Resource Type	Article

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