NDLI: Cation interactions with putative NMDA receptor-gated channels labeled by [3H]MK-801 in rat cerebral cortex

Content Provider	Semantic Scholar
Author	Greenberg, D. A. Marks, Shelley S.
Copyright Year	1988
Abstract	Polyvalent cations that block excitatory responses to N-methyl-D-aspartate inhibited the binding of [3H]MK-801 to putative N-methyl-D-aspartate receptor-gated channels in brain membranes. The order of potency was Zn2+ greater than La3+ = Cd2+ greater than Mn2+ greater than Co2+ greater than Ni2+ = Mg2+. These findings support the existence of interacting sites on the N-methyl-D-aspartate channel for ionic and organic antagonists, and provide a molecular mechanism for the modulation of excitatory neurotransmission and excitotoxicity by endogenous polyvalent cations.
Starting Page	236
Ending Page	240
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(88)90663-5
PubMed reference number	2852319
Journal	Medline
Volume Number	95
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394088906635
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394088906635?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2888%2990663-5
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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Cation interactions with putative NMDA receptor-gated channels labeled by [3H]MK-801 in rat cerebral cortex