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Gene-Pharmacologial Effects on Exercise-Induced Muscle Gene Expression in Healthy Men
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2015 |
| Abstract | The renin-angiotensin system (RAS) represents an important regulator of blood pressure, fluid volume and vascular response to injury and inflammation whose inappropriate activation results in hypertension, fluid retention and thrombotic/atherogenic effects [1]. The octapeptide angiotensin 2 which is produced through angiotensin converting enzyme (ACE) mediated breakdown of angiotensin 1 is involved in most of the effects of RAS on target tissues. Angiotensin 2 mainly binds on G protein-coupled receptors type 1 (ATR1) resulting in vasoconstriction, whereas the less abundantly binding of angiotensin 2 on ATR2 mediates opposing effects such as NO-release and vasodilation. Relating to the cardiovascular system, ATR2 expresses in different compartments and the adjustable degree of expression is thought to partly regulate the vasodilatatory response [2]. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.omicsonline.org/open-access/genepharmacologial-effects-on-exerciseinduced-muscle-geneexpression-in-healthy-men-2161-0940-S5-005.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
