NDLI: Asymptomatic herpes simplex virus type 2 (HSV-2) infection among pregnant women in Turkey.

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Asymptomatic herpes simplex virus type 2 (HSV-2) infection among pregnant women in Turkey.

Content Provider	Semantic Scholar
Author	Duran, Nizami Yarkin, Fugen Evruke, Cuneyt Koksal, Fatih
Copyright Year	2004
Abstract	BACKGROUND & OBJECTIVES A large proportion of individuals with serologic evidence of infection with herpes simplex virus type 2 (HSV-2) are asymptomatic. HSV-2 is the main cause of genital herpes infections. The acquisition of genital herpes during pregnancy has been associated with spontaneous abortion, premature labour and congenital and neonatal herpes. The present study was undertaken to determine asymtomatic genital HSV-2 shedding and seroprevalence of HSV-2 infection among asymptomatic pregnant women at the time of delivery in Adana, Turkey. METHODS Asymptomatic 130 pregnant women without a history of genital herpes were enrolled in the study. HSV-2 shedding was determined by viral culture of the swabs collected from cervix and vulva and HSV-2 antigen was detected by direct immunofluorescence assay (IFA), HSV-2 IgG and IgM antibodies were detected by HSV-2 type specific IgG and IgM enzyme-linked immunosorbent assay (ELISA). RESULTS HSV-2 IgG and IgM antibodies were found in 82 (63.1%) and 18 (11.3%) of 130 pregnant women. HSV-2 type-specific antigen was detected in 22 (16.9%) pregnant women by IFA test, 17 (13.1%) of whom had HSV-2 IgM antibodies. HSV-2 was isolated only in 3 women. INTERPRETATION & CONCLUSION The seroprevalence of HSV-2 (63.1%) and genital HSV-2 infection (16.9%) was high among asymptomatic pregnant women in Adana, Turkey. Therefore, to reduce the risk of neonatal herpes, HSV-2 type-specific antibodies should be detected in pregnant women using serological tests that allow to identify women with asymptomatic or subclinical genital HSV-2 infection and those susceptible to primary genital HSV-2 infection.
File Format	PDF HTM / HTML
PubMed reference number	15347860
Journal	Medline
Volume Number	120
Issue Number	2
Alternate Webpage(s)	http://icmr.nic.in/ijmr/2004/0805.pdf
Journal	The Indian journal of medical research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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