NDLI: RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis.

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RAI3 is overexpressed in gastric adenocarcinoma but unrelated to prognosis.

Content Provider	Semantic Scholar
Author	Melling, Nathaniel Bachmann, Kai A. Bockhorn, Maximillian Mann, Oliver Izbicki, Jakob Robert Grupp, Katharina
Copyright Year	2019
Abstract	PURPOSE Retinoic acid-induced gene 3 (RAI3) has been associated with tumorigeneses in several cancer types. To clarify the clinical significance of RAI3 expression in premalignant and malignant gastric epithelium, RAI3 protein expression was assessed by immunohistochemistry on tissue microarrays (TMAs) containing 140 gastric dysplasia and 230 GC samples. FINDINGS RAI3 protein expression was predominantly localized in the cell membrane and was detectable in low intensities in most of the benign gastric tissue samples. RAI3 expression was found in increased intensities in premalignant and malignant epithelium relative to non-malignant gastric epithelium (P < 0.0001). High RAI3 expression was found in 66.2% of interpretable gastric adenocarcinomas and was associated with advanced pathological tumor stage (P = 0.0014) and positive lymph node status (P = 0.0137) but was unrelated to overall survival of patients (P = 0.3743). CONCLUSION The deregulation of RAI3 in premalignant and gastric epithelium suggests a relevant role of RAI3 during gastric carcinogenesis. Additionally, RAI3 overexpression defines a subset of GCs with aggressive tumor features. However, since RAI3 expression was not associated with clinical outcome of patients, RAI3 cannot be considered as a prognostic biomarker in patients with GCs.
Starting Page	606
Ending Page	612
Page Count	7
File Format	PDF HTM / HTML
PubMed reference number	31933866
Journal	Medline
Volume Number	12
Issue Number	2
Alternate Webpage(s)	http://www.ijcep.com/files/ijcep0086079.pdf
Journal	International journal of clinical and experimental pathology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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