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Differential macrophage requirements for T helper cell and T helper cell-induced B lymphocyte proliferation
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bandeira, Antônio Pobor, Grgur Petterson, S. R. Coutinho, António |
| Copyright Year | 1983 |
| Abstract | Major histocompatibility complex-restricted helper T cell clones against "minor" antigens expressed on B cell and macrophage surfaces, when confronted with appropriate T cell-depleted spleen cells, are induced to proliferation and, in turn, activate "target-responder" B cells to polyclonal growth and maturation. Irradiation of helper cell populations, however, demonstrates that their effector functions (and B lymphocyte responses) are independent of proliferative activity. Adherent cell depletion on Sephadex G10 columns, while completely abrogating helper T cell proliferation, does not abolish helper cell-induced B cell responses, demonstrating a remarkable quantitative difference in macrophage requirements for the growth of these two cell types. Because significant B cell responses are detected upon interaction with primed helper T cells under conditions of extreme macrophage depletion, we conclude that the role of macrophages in T-B cell cooperation is limited to expansion of optimal numbers of helper T lymphocytes. It follows that activated helper cells can autonomously produce all B cell-specific growth and maturation factors mediating cooperative antibody responses. In contrast, the profound reduction of LPS-induced responses upon macrophage depletion suggests accessory cell production of such factors in thymus-independent B cell growth and/or maturation. |
| Starting Page | 312 |
| Ending Page | 323 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 6217279 |
| Volume Number | 157 |
| Journal | The Journal of experimental medicine |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/6f/1e/je1571312.PMC2186895.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antigen-Presenting Cells B-Lymphocytes Biologic Development Cell Proliferation Helper-Inducer T-Lymphocyte Leukemia, B-Cell Lymphocyte Count measurement Major Histocompatibility Complex Spleen Tissue Thymic Tissue cell growth cell type childhood lymphocyte depletion Hodgkin's lymphoma |
| Content Type | Text |
| Resource Type | Article |
