NDLI: DNA vaccines encoding proteins from wild-type and attenuated canine distemper virus protect equally well against wild-type virus challenge

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DNA vaccines encoding proteins from wild-type and attenuated canine distemper virus protect equally well against wild-type virus challenge

Content Provider	Semantic Scholar
Author	Nielsen, Line Jensen, Trine Hammer Kristensen, Birte Jensen, Tove Dannemann Karlskov-Mortensen, Peter Lund, Morten Enemark Aasted, Bent Blixenkrone-Møller, Merete
Copyright Year	2012
Abstract	Immunity induced by DNA vaccines containing the hemagglutinin (H) and nucleoprotein (N) genes of wild-type and attenuated canine distemper virus (CDV) was investigated in mink (Mustela vison), a highly susceptible natural host of CDV. All DNA-immunized mink seroconverted, and significant levels of virus-neutralizing (VN) antibodies were present on the day of challenge with wild-type CDV. The DNA vaccines also primed the cell-mediated memory responses, as indicated by an early increase in the number of interferon-gamma (IFN-γ)-producing lymphocytes after challenge. Importantly, the wild-type and attenuated CDV DNA vaccines had a long-term protective effect against wild-type CDV challenge. The vaccine-induced immunity induced by the H and N genes from wild-type CDV and those from attenuated CDV was comparable. Because these two DNA vaccines were shown to protect equally well against wild-type virus challenge, it is suggested that the genetic/antigenic heterogeneity between vaccine strains and contemporary wild-type strains are unlikely to cause vaccine failure.
Starting Page	1887
Ending Page	1896
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1007/s00705-012-1375-y
PubMed reference number	22714870
Journal	Medline
Volume Number	157
Alternate Webpage(s)	http://vbn.aau.dk/files/72964445/Nielsen_et_al_2012.pdf
Alternate Webpage(s)	https://doi.org/10.1007/s00705-012-1375-y
Journal	Archives of Virology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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