Loading...
Please wait, while we are loading the content...
Probing DNA and RNA single molecules with a double optical tweezer
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mangeol, Pierre Côté, Dominique Bizebard, Thierry Legrand, Olivier Bockelmann, Ulrich |
| Copyright Year | 2006 |
| Abstract | Abstract.A double-tweezer setup is used to induce mechanical stress in systems of molecular biology. A double strand of DNA is first stretched and the data is compared to precedent experiments to check the experimental setup. Then a short foldable fragment of RNA is probed; the typical unfolding/refolding hysteresis behaviour of this kind of construction is shown and followed by a study of its elasticity and a comparison to a worm-like chain model. Eventually, we describe the unfolding of a larger RNA structure, which unfolds by multiple steps. We show that this unfolding is not reversible and that it presents numerous unfolding pathways. |
| Starting Page | 311 |
| Ending Page | 317 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1140/epje/i2005-10060-4 |
| Alternate Webpage(s) | https://www.nbp.espci.fr/publications/EurPhys_2006.pdf |
| PubMed reference number | 16485070 |
| Alternate Webpage(s) | https://doi.org/10.1140/epje%2Fi2005-10060-4 |
| Journal | Medline |
| Volume Number | 19 |
| Journal | The European physical journal. E, Soft matter |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
