NDLI: Structure and dynamics of bio-hydrogels investigated by neutron and X-ray scattering techniques

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Structure and dynamics of bio-hydrogels investigated by neutron and X-ray scattering techniques

Content Provider	Semantic Scholar
Author	Chiapponi, Chiara
Copyright Year	2010
Abstract	Hyaluronic acid (HYA) is a natural polysaccharide, belonging to the family of glycosaminoglycans, characterized by the repetition of a disaccharide unit of glucuronic acid and N-acetylglucosamine. HYA is present throughout the animal kingdom, from the extracellular matrices in which most tissues differentiate, to the vitreous of the human eye and the synovial joint fluid. Thanks to its ability to form viscous solutions in water, HYA is widely used to treat inflammatory and degenerative joint diseases, a group of pathologies with a high impact in society since they contribute heavily to the rise of health costs and they affect life quality. Beside HYA, we investigated a chemically modified form of hyaluronic acid, HYADD, obtained derivatizing the polysaccharide backbone with hexadecylic (C16) side chains, through amide bonds, with a 1-3 mol-% degree of substitution of repeating units. Even if the modification is very small, it alters dramatically some macroscopic properties such as the elastic behavior and the rheological response. The resulting system is a relatively stable hydrogel at polymer concentrations higher than 0.3% (weight of polymer/total volume), whereas native hyaluronic acid forms highly viscous solutions only at concentrations ten times higher. HYADD, however, does not differ from HYA in other relevant features such as charge density along the chain and swelling ability, as well as in its interaction behavior with metabolites and cellular material in the synovial matrix. On the basis of the beneficial
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dspace-unipr.cineca.it/bitstream/1889/1380/1/PhD_Thesis.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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