NDLI: Left Atrial Appendage Closure – The WATCHMAN Device

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Left Atrial Appendage Closure – The WATCHMAN Device

Content Provider	Semantic Scholar
Author	Akinapelli, Abhilash Bansal, Ojas Chen, Jack P. Pflugfelder, Alex Gordon, Nicole T. Stein, Kenneth M. Huibregtse, Barbara A. Hou, Dongming
Copyright Year	2015
Abstract	Atrial fibrillation (AF) is one of the most common arrhythmias seen in clinical cardiology practice. Patients with non-valvular AF have an approximately 5-fold increase in the risk of stroke, with an exponential increase with advancing age. Cardioembolic strokes carry a high mortality risk. Although the potential of warfarin to reduce systemic embolization in AF patients is well established, its use is difficult due to narrow therapeutic windows and additional complications (e.g. increased risk of bleeding), especially for aging patients. Therefore, alternative means of treatment to reduce stroke risk in these patients are needed. The left atrial appendage is the major source of thrombus formation in patients with non-valvular AF. The WATCHMAN device (Boston Scientific, MA) is a percutaneous left atrial appendage closure device which has been tested prospectively in multiple randomized trials. It offers a new stroke risk reduction option for high-risk patients with non-valvular atrial fibrillation who are seeking an alternative to long-term warfarin therapy. Based on the robust WATCHMAN clinical program which consists of numerous studies, with more than 2,400 patients and nearly 6,000 patient-years of follow-up, the WATCHMAN LAAC Device is approved by FDA. In this article we reviewed the preclinical studies and clinical trials, as well as the next generation of the device.
Starting Page	334
Ending Page	340
Page Count	7
File Format	PDF HTM / HTML
PubMed reference number	4774639
Volume Number	11
Journal	Current cardiology reviews
Language	English
Access Restriction	Open
Subject Keyword	Atrial Fibrillation Cardiology discipline Cerebellar Ataxia and Hypogonadotropic Hypogonadism Cerebral Infarction Cerebrovascular accident Closure Embolism Heart Atrium Hemorrhage Hypoplastic Left Heart Syndrome Patients Pharmacology Registration Structure of auricular appendage Thromboembolism Thrombosis Ventricular Fibrillation Warfarin exponential
Content Type	Text
Resource Type	Article

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