NDLI: The inhibition of NOTCH2 reduces UVB-induced damage in retinal pigment epithelium cells

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The inhibition of NOTCH2 reduces UVB-induced damage in retinal pigment epithelium cells

Content Provider	Semantic Scholar
Author	Liu, Lanying Zhou, Xin Kuang, Xielan Long, Chongde Liu, Weiling Tang, Yan Liu, Huijun He, Jia Hui Huang, Zixin Fan, Yuting Zhang, Qingjiong Shen, Huangxuan
Copyright Year	2017
Abstract	Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly. The pathogenesis of dry AMD remains indistinct and the mechanism of retinal pigment epithelium (RPE) cells death in dry AMD is controversial. The aim of the present study was to investigate the functions of Notch signaling in ultraviolet B (UVB)-induced damage of RPE cells. It was identified that, in RPE cells, UVB increased intracellular reactive oxygen species (ROS) and induced cell apoptosis. In addition, UVB activated Notch signaling in a dose dependent manner. Surprisingly, NOTCH2, but not NOTCH1, was demonstrated to be the major Notch receptor in RPE cells. Under normal conditions, the inhibition of NOTCH2 reduced cell growth and cell migration, but had no impact on intracellular ROS and cell apoptosis. However, in the presence of UVB, the inhibition of NOTCH2, but not NOTCH1, attenuated intracellular ROS and cell apoptosis. The function of Notch signaling involved in UVB damage of RPE cells may not only be significant to understanding the pathogenesis of AMD (especially dry AMD), but also useful for designing effective therapeutic agents for dry AMD.
Starting Page	730
Ending Page	736
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.spandidos-publications.com/10.3892/mmr.2017.6625/download
PubMed reference number	28560393v1
Alternate Webpage(s)	https://doi.org/10.3892/mmr.2017.6625
DOI	10.3892/mmr.2017.6625
Journal	Molecular medicine reports
Volume Number	16
Language	English
Access Restriction	Open
Subject Keyword	Apoptosis Dry Eye Syndromes Macular degeneration NOTCH2 gene Reactive Oxygen Species Retina Retinal Pigments Structure of retinal pigment epithelium Ultraviolet B radiation cell growth
Content Type	Text
Resource Type	Article

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