NDLI: Molecular Recognition of Saccharides using Boronic Acids

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Molecular Recognition of Saccharides using Boronic Acids

Content Provider	Semantic Scholar
Author	Galbraith, Ewan Fossey, John S. James, Tony D.
Copyright Year	2008
Abstract	Fluorescence is a highly sensitive technique; it is possible to detect single molecules. Fluorescence can also be switched between 'on' and 'off' states; this property can be used to produce a digital response to target molecules. Therefore, fluorescence is the obvious choice in the investigation of molecule-molecule recognition events in chemistry and biology. Fluorescent and colorimetric sensors for saccharides and related species have been developed based on the interaction between a boronic acid and a diol. The measurements of saccharide concentrations are important in the medicinal field (D-glucose and diabetics) and food industries (D-glucose and brewing; D-fructose and confectionery). 1 Boronate Affinity Saccharide Electrophoresis (BASE) is a novel tool in saccharide analysis currently being investigated within our group. With the huge diversity of biological systems which utilise sugar groups, we envisage BASE becoming a routine part of carbohydrate assays. We have also developed solution phase molecular systems capable of chiral discrimination. 2 Most naturally occurring chemical species, including sugars and sugar acids, are chiral compounds, therefore a chiral sensor is inherently better than an achiral one. It is hoped that the colorimetric sensors can be incorporated into simple diagnostic test papers, similar to universal indicator (pH) paper. Such systems would make it possible to measure the concentration of target species without the need of specialist instrumentation. Another current area of interest involves research into the production of glucose-monitoring contact lenses.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://johnfossey.com/publications/RSC_OralAbstract10.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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