Activity of the Basal Ganglia in Schizophrenia and Bipolar Disorder

Content Provider	Semantic Scholar
Author	Nandyalam Gayathri Gejman, Pablo Taricco, Angela Raghunathan, K. S.
Copyright Year	2018
Abstract	Schizophrenia, bipolar disorder, and schizoaffective disorder are three common, yet uncured, neurological disorders. The majority of research investigating the pathology and etiology of these diseases is conducted directly on patients in laboratory settings. Few studies have used neuroimaging to study potential areas of cause of the disorders. In this study, neuroimaging techniques were utilized to investigate activity levels in the basal ganglia, the region of the brain primarily responsible for motor control, executive function, behavior, and emotion. Similar brain activity was expected in the basal ganglia because of the mood similarities among patients with these disorders. Statistical parametric mapping was used to extract parametric data from the voxels located in the regions of interest (ROIs). Data was exported for a one-way ANOVA, yielding a p-value of 1.7612E-07; there was a significant difference between patient groups. Activity levels may not correspond to potential areas of common root cause. However, these disorders could still share genetic similarities and future work would investigate commonalities between the distribution of neuronal signaling chemical regulators.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://users.wpi.edu/~gnandyalam/WorkDocumentation/Update1/STEMTHESIS2018_SUBMIT_PRINT.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article