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Side chain homologation of alanyl peptide nucleic acids: pairing selectivity and stacking.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Diederichsen, Ulf Weicherding, Daniel Diezemann, Nicola |
| Copyright Year | 2005 |
| Abstract | Alanyl peptide nucleic acids (alanyl-PNAs) are oligomers based on a regular peptide backbone with alternating configuration of the amino acids. All side chains are modified by covalently linked nucleobases. Alanyl-PNAs form very rigid, well defined, and linear double strands based on hydrogen bonding of complementary strands, stacking, and solvation. Side chain homology was examined by comparing a methylene linker (alanyl-PNA) with an ethylene linker (homoalanyl-PNA), a trimethylene linker (norvalyl-PNA), and PNA sequences with mixed linker length between nucleobase and backbone. Side chain homology in combination with a linear double strand topology turned out to be valuable in order to selectively manipulate pairing selectivity (pairing mode) and base pair stacking. |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/B411545G |
| PubMed reference number | 15750649 |
| Journal | Medline |
| Volume Number | 3 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/ob/b4/b411545g/b411545g1.pdf |
| Alternate Webpage(s) | https://doi.org/10.1039/B411545G |
| Journal | Organic & biomolecular chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
