NDLI: Inhibition of Axon Growth by Oligodendrocyte Precursor Cells

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Inhibition of Axon Growth by Oligodendrocyte Precursor Cells

Content Provider	Semantic Scholar
Author	Chen, Z. J. Ughrin, Yvonne M. Levine, Joel Martin
Copyright Year	2002
Abstract	The glial scar that forms at the site of injury is thought to be a biochemical and physical barrier to successful regeneration, although the molecules responsible for this barrier function are not well understood. Glia scars contain large numbers of oligodendrocyte precursor cells (OPCs) and these cells can produce several different growth-inhibitory chondroitin sulfate proteoglycans (CSPGs), including NG2, neurocan, and phosphacan. Here, we used membrane-based assays to show that the surface of OPCs is both nonpermissive and inhibitory for neurite outgrowth. Inhibition of growth by OPC is reversed by treatment with antibodies against the NG2 CSPG and the expression of NG2 is sufficient to change a growth-permissive cell surface to a nonpermissive surface. These result suggest that the OPCs that accumulate rapidly at sites of CNS injury can contribute to the creation of an environment that inhibits nerve regeneration and that NG2 is a necessary feature of that environment.
Starting Page	125
Ending Page	139
Page Count	15
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://labs.icb.ufmg.br/lbcd/prodabi5/homepages/hugo/Hugo/neuroregeneracao6.pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S1044743102911024
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S1044743102911024?dgcid=api_sd_search-api-endpoint
PubMed reference number	12056844v1
Alternate Webpage(s)	https://doi.org/10.1006/mcne.2002.1102
DOI	10.1006/mcne.2002.1102
Journal	Molecular and Cellular Neuroscience
Volume Number	20
Language	English
Access Restriction	Open
Subject Keyword	Axon Chondroitin Sulfate Proteoglycans Chondroitin Sulfates Cicatrix NCAN gene Natural regeneration Nerve Regeneration Neuroglia Oligodendroglia Protein Tyrosine Phosphatase, Receptor Type Z Proteoglycan Tissue membrane childhood central nervous system germ cell tumor
Content Type	Text
Resource Type	Article

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Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition.

NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors.

Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.

The glial response to injury and its role in the inhibition of CNS repair.

Diverse functions of protein tyrosine phosphatase σ in the nervous and immune systems

Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism.

The brain chondroitin sulfate proteoglycan brevican associates with astrocytes ensheathing cerebellar glomeruli and inhibits neurite outgrowth from granule neurons.

Inhibition of central axon regeneration: perspective from chondroitin sulfate proteoglycans in lamprey spinal cord injury.

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Inhibition of Axon Growth by Oligodendrocyte Precursor Cells

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Axonal regeneration through regions of chondroitin sulfate proteoglycan deposition after spinal cord injury: a balance of permissiveness and inhibition.

NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors.

Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.

The glial response to injury and its role in the inhibition of CNS repair.

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Inhibition of Axon Growth by Oligodendrocyte Precursor Cells