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Reduction of coronary reserve: a mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Opherk, Dieter Mall, Gerhard Zebe, H. Schwarz, F. Weihe, E. Manthey, Joachim Kuebler, Wolfgang |
| Copyright Year | 1984 |
| Abstract | The pathogenesis of angina pectoris in patients with left ventricular hypertrophy secondary to arterial hypertension and with normal coronary arteries remains uncertain. We measured coronary blood flow (argon method) in 12 control subjects and in 16 patients with arterial hypertension at rest and after intravenous administration of dipyridamole (0.5 mg/kg). In the patients with arterial hypertension, coronary blood flow response to dipyridamole was markedly reduced (p less than .001 as compared with control values). During coronary vasodilation there was a linear correlation between coronary resistance and left ventricular end-diastolic pressure (r = .67, p less than .001). Left ventricular catheter biopsy specimens did not reveal alterations in myocardial microvasculature. These findings suggest that reduction of coronary reserve may be an important contributor to the pathogenesis of angina pectoris in these patients. |
| Starting Page | 1 |
| Ending Page | 7 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1161/01.CIR.69.1.1 |
| PubMed reference number | 6689632 |
| Journal | Medline |
| Volume Number | 69 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/69/1/1.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/69/1/1.full.pdf?download=true |
| Alternate Webpage(s) | https://doi.org/10.1161/01.CIR.69.1.1 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
