NDLI: Pancreatic beta cell lines and their applications in diabetes mellitus research.

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Pancreatic beta cell lines and their applications in diabetes mellitus research.

Content Provider	Semantic Scholar
Author	Skelin, Maša Rupnik, Marjan Cencic, Avrelija
Copyright Year	2010
Abstract	During the past 30 years great effort has been put into establishing an insulin-secreting beta cell line that retains normal regulation of insulin secretion, but only few of these attempts have been successful. To overcome the limited availability of primary beta cells and to include the principles of the 3Rs into the field of diabetes mellitus research, numerous investigators used X-rays or viruses to induce insulinomas, in vitro transformation, derivation of cells from transgenic mice or even non-islet cells to produce immortalised beta cell lines. The most widely used insulin-secreting cell lines are RIN, HIT, MIN, INS-1 and TC cells. These cells produce insulin and small amounts of glucagon and somatostatin. Some of them are only poorly responsive to glucose, others respond to glucose well, but their concentration-dependence curve is markedly shifted to higher sensitivity. Despite problems associated with beta cell cultures, these cell lines have provided some valuable information about physiological processes. However, an urgent need to establish a "normal" beta cell line of human or pig origin remains.
Starting Page	62
Ending Page	62
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.altex.ch/resources/altex_2010_2_105_113_Skelin2.pdf
PubMed reference number	20686743v1
Volume Number	27
Issue Number	2
Journal	ALTEX
Language	English
Access Restriction	Open
Subject Keyword	Cell Culture Techniques Cell secretion Cellular Phone Cultured Cell Line Diabetes Mellitus Glucose Physiological Processes RIT2 gene Rajiformes Structure of beta Cell of islet Technetium Thrombocytopenia insulinoma
Content Type	Text
Resource Type	Article

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