NDLI: The effects of dexmedetomidine infusion on renal functions after coronary artery bypass graft surgery: a randomized, double-blind, placebo-controlled study

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The effects of dexmedetomidine infusion on renal functions after coronary artery bypass graft surgery: a randomized, double-blind, placebo-controlled study

Content Provider	Semantic Scholar
Author	Göksedef, Deniz
Copyright Year	2013
Abstract	Amac: Bu calismada deksmedetomidinin koroner arter baypas greft (KABG) cerrahisini takiben renal fonksiyonlar uzerindeki muhtemel etkileri arastirildi. Calisma plani: 2008 Agustos 2009 Mayis tarihleri arasinda klinigimizde KABG cerrahisi uygulanan ardisik 100 hasta bu cift kor ve plasebo kontrollu calismaya dahil edildi. Hastalar deksmedetomidin infuzyonu veya plaseboya randomize edildi. Hastalarin sedasyon duzeyi, Ramsey Sedasyon Skalasi kullanilarak duzenlendi. Dortlu permutasyon bloklari yontemi kullanilarak, hastalar randomize edildi. Bul gu lar: Deksmedetomidin grubunda 49, plasebo grubunda 37 hasta olmak uzere, toplam 86 hasta analize tabi tutuldu. Gruplar arasinda major ameliyat sirasi ve sonrasi degiskenler acisindan istatistiksel olarak anlamli bir farklilik yoktu. Gruplar arasinda ameliyat sonrasi 1. gun kreatinin klirensi duzeyleri acisindan, 110 μg/gun kesim degeri uzerinde anlamli farklilik oldugu saptandi. Bu degisikliklerin ameliyat sonrasi 5. gun kreatinin klirensi duzeylerinde olmadigi belirlendi. Sonuc:Dusuk doz deksmedetomidinin idrar cikisi ve kan ure, kreatinin ve kreatinin klirensi gibi renal fonksiyon gostergeleri uzerinde belirgin etkisi yoktur. Ancak toplam dozdaki artisa bagli olarak, renal fonksiyonlar uzerinde pozitif bir etkisi olabilir. Anah tar soz cuk ler: Koroner arter baypas greft cerrahisi; deksmedetomidin; renal fonksiyon. Background: This study aims to investigate possible effects of dexmedetomidine on renal functions following coronary artery bypass graft (CABG) surgery. Methods: Between August 2008 and May 2009, consecutive 100 patients who underwent CABG surgery in our clinic were included in this double-blind and placebo-controlled study. Patients were randomized to either dexmedetomidine infusion or placebo. The sedation level of the patients was regulated using Ramsey Sedation Scale. Permuted blocks of four method was used to randomize patients. Results: A total of 86 patients were included in the analysis including 49 in the dexmedetomidine group and 37 in the placebo group. There was no statistically significant difference in major intraoperative and postoperative variables between the groups. Postoperative day 1 creatinine clearances values above cut-off point of 110 μg/day were significantly different between the groups. These changes were not observed in postoperative fifth day creatinine clearances values. Conclusion: Low dose dexmedetomidine has no major effect on urine output and renal indices such as urea, creatinine and creatinine clearances. However, it may have a positive effect on renal functions when total dose is uptitrated, particularly.
Starting Page	594
Ending Page	602
Page Count	9
File Format	PDF HTM / HTML
DOI	10.5606/tgkdc.dergisi.2013.7645
Volume Number	21
Alternate Webpage(s)	http://tgkdc.dergisi.org/uploads/pdf/pdf_TGKDC_1831.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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