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Tumor suppressing potential of Cajanus cajan in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch carcinogenesis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hemalatha, K. Manoharan, Shanmugam Begum, Musthafa Shabana Neelakandan, Mani |
| Copyright Year | 2017 |
| Abstract | Traditional medicine has explored the diverse pharmacological efficacy of Cajanus cajan leaves including anti-inflammatory and antioxidant potential. To scientifically validate the tumor inhibitory potential of Cajanus cajan leaves, the present study utilized the 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis as an experimental oral cancer model. The ethanolic extract of Cajanus cajan leaves (CcELet) suppressed the tumor formation in the pre- initiation phase and reduced the formation of tumors and tumor size as well in the post-initiation phase. Also, the Cajanus cajan leaves modulated the status of lipid peroxidation, antioxidants, and phase I and phase II detoxification agents towards tumor inhibition in the hamsters treated with DMBA. The results of the study thus explore the anti-tumor potential of Cajanus cajan leaves during DMBA induced hamster buccal pouch carcinogenesis. Keywords: Cajanus cajan; oral cancer; lipid peroxidation; antioxidants; detoxification agents. |
| Starting Page | 504 |
| Ending Page | 511 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Volume Number | 8 |
| Alternate Webpage(s) | https://www.pharmascope.org/index.php/ijrps/article/download/1061/645 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
